StemRegenin-1 Attenuates Endothelial Progenitor Cell Senescence by Regulating the AhR Pathway-Mediated CYP1A1 and ROS Generation

StemRegenin-1 Attenuates Endothelial Progenitor Cell Senescence by Regulating the AhR Pathway-Mediated CYP1A1 and ROS Generation

Endothelial progenitor cell (EPC)-based stem cell therapy is a promising therapeutic strategy for vascular diseases. However, continuous in vitro expansion for clinical studies induces the loss of EPC functionality due to aging. In this study, we investigated the effects of StemRegenin-1 (SR-1), an...

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Bibliographic Details
Main Authors: Hye Ji Lim, Woong Bi Jang, Vinoth Kumar Rethineswaran, Jaewoo Choi, Eun Ji Lee, Sangmi Park, Yeoreum Jeong, Jong Seong Ha, Jisoo Yun, Young Jin Choi, Young Joon Hong, Sang-Mo Kwon
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
StemRegenin-1
human endothelial progenitor cells
AhR pathway
reactive oxygen species
replicative senescence
Online Access:https://www.mdpi.com/2073-4409/12/15/2005

Internet

https://www.mdpi.com/2073-4409/12/15/2005

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