Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.
The HLA-B*35-Px allele has been associated with rapid disease progression in HIV-1 infection, in contrast to the HLA-B*35-Py allele.Immune responses to two HLA-B*35 restricted HIV-1 specific CTL epitopes and their variants were followed longitudinally during early HIV-1 infection in 16 HLA-B*35+ ind...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-04-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2858076?pdf=render |
| _version_ | 1818949692954771456 |
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| author | Christian B Willberg Keith E Garrison R Brad Jones Duncan A Meiklejohn Gerald Spotts Teri J Liegler Mario A Ostrowski Annika C Karlsson Frederick M Hecht Douglas F Nixon |
| author_facet | Christian B Willberg Keith E Garrison R Brad Jones Duncan A Meiklejohn Gerald Spotts Teri J Liegler Mario A Ostrowski Annika C Karlsson Frederick M Hecht Douglas F Nixon |
| author_sort | Christian B Willberg |
| collection | DOAJ |
| description | The HLA-B*35-Px allele has been associated with rapid disease progression in HIV-1 infection, in contrast to the HLA-B*35-Py allele.Immune responses to two HLA-B*35 restricted HIV-1 specific CTL epitopes and their variants were followed longitudinally during early HIV-1 infection in 16 HLA-B*35+ individuals. Subjects expressing HLA-B*35-Px alleles showed no difference in response to the consensus epitopes compared to individuals with HLA-B*35-Py alleles. Surprisingly, all the HLA-B*35-Px+ individuals responded to epitope-variants even in the absence of a consensus response. Sequencing of the viral population revealed no evidence of variant virus in any of the individuals.This demonstrates a novel phenomenon that distinguishes individuals with the HLA-B*35-Px rapid progressing allele and those with the HLA-B*35-Py slower progressing allele. |
| first_indexed | 2024-12-20T09:06:44Z |
| format | Article |
| id | doaj.art-3b560a8f800a4a6e8085dcbcfcb3e7d5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T09:06:44Z |
| publishDate | 2010-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3b560a8f800a4a6e8085dcbcfcb3e7d52022-12-21T19:45:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-04-0154e1024910.1371/journal.pone.0010249Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.Christian B WillbergKeith E GarrisonR Brad JonesDuncan A MeiklejohnGerald SpottsTeri J LieglerMario A OstrowskiAnnika C KarlssonFrederick M HechtDouglas F NixonThe HLA-B*35-Px allele has been associated with rapid disease progression in HIV-1 infection, in contrast to the HLA-B*35-Py allele.Immune responses to two HLA-B*35 restricted HIV-1 specific CTL epitopes and their variants were followed longitudinally during early HIV-1 infection in 16 HLA-B*35+ individuals. Subjects expressing HLA-B*35-Px alleles showed no difference in response to the consensus epitopes compared to individuals with HLA-B*35-Py alleles. Surprisingly, all the HLA-B*35-Px+ individuals responded to epitope-variants even in the absence of a consensus response. Sequencing of the viral population revealed no evidence of variant virus in any of the individuals.This demonstrates a novel phenomenon that distinguishes individuals with the HLA-B*35-Px rapid progressing allele and those with the HLA-B*35-Py slower progressing allele.http://europepmc.org/articles/PMC2858076?pdf=render |
| spellingShingle | Christian B Willberg Keith E Garrison R Brad Jones Duncan A Meiklejohn Gerald Spotts Teri J Liegler Mario A Ostrowski Annika C Karlsson Frederick M Hecht Douglas F Nixon Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes. PLoS ONE |
| title | Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes. |
| title_full | Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes. |
| title_fullStr | Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes. |
| title_full_unstemmed | Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes. |
| title_short | Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes. |
| title_sort | rapid progressing allele hla b35 px restricted anti hiv 1 cd8 t cells recognize vestigial ctl epitopes |
| url | http://europepmc.org/articles/PMC2858076?pdf=render |
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