What evidence is there for implicating the brain orexin system in neuropsychiatric symptoms in dementia?

Neuropsychiatric symptoms (NPS) affect people with dementia (PwD) almost universally across all stages of the disease, and regardless of its exact etiology. NPS lead to disability and reduced quality of life of PwD and their caregivers. NPS include hyperactivity (agitation and irritability), affecti...

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Bibliographic Details
Main Authors: Giorgio Bergamini, Preciosa Coloma, Helene Massinet, Michel Alexander Steiner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Psychiatry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1052233/full