Age-related changes in human bone marrow mesenchymal stromal cells: morphology, gene expression profile, immunomodulatory activity and miRNA expression

Age-related changes in human bone marrow mesenchymal stromal cells: morphology, gene expression profile, immunomodulatory activity and miRNA expression

IntroductionMesenchymal stromal cells (MSC) are one of the main cellular components of bone marrow (BM) microenvironment. MSC play a key role in tissue regeneration, but they are also capable of immunomodulating activity. With host aging, MSC undergo age-related changes, which alter these functions,...

Full description

Bibliographic Details
Main Authors: Fulvio Massaro, Florent Corrillon, Basile Stamatopoulos, Nathan Dubois, Achille Ruer, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stromal cells
bone marrow
aging
immunomodulation
macrophage polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267550/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267550/full

Similar Items