BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells

BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells

Bone defects and non-union are prevalent in clinical orthopedy, and the outcomes of current treatments are often suboptimal. Bone tissue engineering offers a promising approach to treating these conditions effectively. Bone morphogenetic protein 9 (BMP9) can commit mesenchymal stem cells to osteogen...

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Bibliographic Details
Main Authors: Jie Zhang, Jinhai Jiang, Hang Liu, Shiyu Wang, Kaixin Ke, Siyuan Liu, Yue Jiang, Lu Liu, Xiang Gao, Baicheng He, Yuxi Su
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-05-01
Series:Genes and Diseases
Subjects:
BMP9
LGR4
mTORC1
Osteogenic differentiation
Stat3
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223003586

Internet

http://www.sciencedirect.com/science/article/pii/S2352304223003586

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