C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity

C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity

Abstract The blood-brain barrier (BBB) serves as a highly intricate and dynamic interface connecting the brain and the bloodstream, playing a vital role in maintaining brain homeostasis. BBB dysfunction has been associated with multiple neurodegenerative diseases, including amyotrophic lateral scler...

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Bibliographic Details
Main Authors: Ana Aragón-González, Allan C Shaw, Jannigje R Kok, Florence S Roussel, Cleide dos Santos Souza, Sarah M Granger, Tatyana Vetter, Yolanda de Diego, Kathrin C Meyer, Selina N Beal, Pamela J Shaw, Laura Ferraiuolo
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Fluids and Barriers of the CNS
Subjects:
Stem cells
Blood brain barrier
Amyotrophic lateral sclerosis
C9ORF72
In vitro modelling
Neurodegeneration
Online Access:https://doi.org/10.1186/s12987-024-00528-6

Internet

https://doi.org/10.1186/s12987-024-00528-6

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