C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity

C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity

Abstract The blood-brain barrier (BBB) serves as a highly intricate and dynamic interface connecting the brain and the bloodstream, playing a vital role in maintaining brain homeostasis. BBB dysfunction has been associated with multiple neurodegenerative diseases, including amyotrophic lateral scler...

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Bibliographic Details
Main Authors:	Ana Aragón-González, Allan C Shaw, Jannigje R Kok, Florence S Roussel, Cleide dos Santos Souza, Sarah M Granger, Tatyana Vetter, Yolanda de Diego, Kathrin C Meyer, Selina N Beal, Pamela J Shaw, Laura Ferraiuolo
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Series:	Fluids and Barriers of the CNS
Subjects:	Stem cells Blood brain barrier Amyotrophic lateral sclerosis C9ORF72 In vitro modelling Neurodegeneration
Online Access:	https://doi.org/10.1186/s12987-024-00528-6

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