The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages

The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages

Dysregulated neutrophilic inflammation can be highly destructive in chronic inflammatory diseases due to prolonged neutrophil lifespan and continual release of histotoxic mediators in inflamed tissues. Therapeutic induction of neutrophil apoptosis, an immunologically silent form of cell death, may b...

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Bibliographic Details
Main Authors: Kimberly D. Herman, Carl G. Wright, Helen M. Marriott, Sam C. McCaughran, Kieran A. Bowden, Mark O. Collins, Stephen A. Renshaw, Lynne R. Prince
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
neutrophil
inflammation
COPD
neutrophil apoptosis
efferocytosis
mouse lung injury model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.956991/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.956991/full

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