Proprotein convertase 1/3-mediated down-regulation of brain-derived neurotrophic factor in cortical neurons induced by oxygen-glucose deprivation

Proprotein convertase 1/3-mediated down-regulation of brain-derived neurotrophic factor in cortical neurons induced by oxygen-glucose deprivation

Brain-derived neurotrophic factor (BDNF) has robust effects on synaptogenesis, neuronal differentiation and synaptic transmission and plasticity. The maturation of BDNF is a complex process. Proprotein convertase 1/3 (PC1/3) has a key role in the cleavage of protein precursors that are directed to r...

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Bibliographic Details
Main Authors: Xiang-Yang Zhang, Feng Liu, Yan Chen, Wei-Chun Guo, Zhao-Hui Zhang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
cortical neuron; ischemia; neurotrophin; oxygen-glucose deprivation; precursor protein of brain-derived neurotrophic factor; proprotein convertase; proprotein convertase 1/3
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=6;spage=1066;epage=1070;aulast=Zhang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=6;spage=1066;epage=1070;aulast=Zhang

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