Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy

Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy

Decidualization, denoting the transformation of endometrial stromal cells into specialized decidual cells, is a prerequisite for normal embryo implantation and a successful pregnancy in human. Here, we demonstrated that knockout of Gαq lead to an aberrantly enhanced inflammatory state during decidua...

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Bibliographic Details
Main Authors: Yufei Jiang, Yan He, Songting Liu, Gaizhen Li, Dunjin Chen, Wenbo Deng, Ping Li, Ying Zhang, Jinxiang Wu, Jianing Li, Longmei Wang, Jiajing Lin, Haibin Wang, Shuangbo Kong, Guixiu Shi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
decidualization
early pregnancy
Gαq-PKD/PKCμ
HDAC5
inflammatory cytokine
Online Access:https://elifesciences.org/articles/83083

Internet

https://elifesciences.org/articles/83083

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