Introducing a Novel Biorelevant In Vitro Dissolution Method for the Assessment of Nicotine Release from Oral Tobacco-Derived Nicotine (OTDN) and Snus Products

The rate at which oral tobacco-derived nicotine (OTDN) and snus pouches release nicotine into saliva is crucial to determine product performance. As no standardized method is available for this purpose, this study sought to develop a biorelevant dissolution method that could both discriminate betwee...

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Bibliographic Details
Main Authors: Matthias M. Knopp, Nikolai K. Kiil-Nielsen, Anna E. Masser, Mikael Staaf
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Separations
Subjects:
Online Access:https://www.mdpi.com/2297-8739/9/2/52