Studies on the role of Rosa roxburghii Tratt quercetin in improving intestinal metabolism and the microbiome in mice with Alzheimer's disease
To explore the possible pathways and biomarkers of the influence of Rosa roxburghii Tratt (RRT) quercetin on intestinal microbiota and its metabolites in the pathogenesis of Alzheimer’s disease (AD), the experiment was divided into normal control (NC) group, model (MC) group, high-dose RRT quercetin...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624000483 |
| _version_ | 1797277344777371648 |
|---|---|
| author | Tingyuan Ren Zhen Chen Jiao Xie Shuming Tan Yuping Zhu |
| author_facet | Tingyuan Ren Zhen Chen Jiao Xie Shuming Tan Yuping Zhu |
| author_sort | Tingyuan Ren |
| collection | DOAJ |
| description | To explore the possible pathways and biomarkers of the influence of Rosa roxburghii Tratt (RRT) quercetin on intestinal microbiota and its metabolites in the pathogenesis of Alzheimer’s disease (AD), the experiment was divided into normal control (NC) group, model (MC) group, high-dose RRT quercetin (HG) group, low-dose RRT quercetin (LG) group and galantamine hydrobromide (Gal) group. The levels of acetylcholine (Ach), acetylcholinesterase (AChE) and choline acetyl transferase (ChAT) in brain tissue were measured. The changes in the microbiome and metabolites in the cecum contents were identified by 16S rRNA gene amplicon sequencing and UPLC/HRMS, respectively. The results showed that RRT quercetin increased the levels of Ach and ChAT in the brain and decreased AChE activity in the brain. The diversity of the intestinal microbiome of AD mice was significantly improved by RRT quercetin. The results showed that RRT quercetin regulates the intestinal microenvironment, intestinal microbiome and metabolites to improve cognitive function in AD mice. |
| first_indexed | 2024-03-07T15:47:18Z |
| format | Article |
| id | doaj.art-3b75f29c07f844c99c52d837d61bc5cb |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-07T15:47:18Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-3b75f29c07f844c99c52d837d61bc5cb2024-03-05T04:29:34ZengElsevierJournal of Functional Foods1756-46462024-03-01114106046Studies on the role of Rosa roxburghii Tratt quercetin in improving intestinal metabolism and the microbiome in mice with Alzheimer's diseaseTingyuan Ren0Zhen Chen1Jiao Xie2Shuming Tan3Yuping Zhu4College of Brewing and Food Engineering, Guizhou University, Guiyang 550025, PR ChinaCollege of Brewing and Food Engineering, Guizhou University, Guiyang 550025, PR ChinaKey Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical University, Guiyang 550025, PR ChinaCollege of Brewing and Food Engineering, Guizhou University, Guiyang 550025, PR ChinaCollege of Basic Medicine, Guizhou Medical University, Guiyang 550025, PR China; Corresponding author.To explore the possible pathways and biomarkers of the influence of Rosa roxburghii Tratt (RRT) quercetin on intestinal microbiota and its metabolites in the pathogenesis of Alzheimer’s disease (AD), the experiment was divided into normal control (NC) group, model (MC) group, high-dose RRT quercetin (HG) group, low-dose RRT quercetin (LG) group and galantamine hydrobromide (Gal) group. The levels of acetylcholine (Ach), acetylcholinesterase (AChE) and choline acetyl transferase (ChAT) in brain tissue were measured. The changes in the microbiome and metabolites in the cecum contents were identified by 16S rRNA gene amplicon sequencing and UPLC/HRMS, respectively. The results showed that RRT quercetin increased the levels of Ach and ChAT in the brain and decreased AChE activity in the brain. The diversity of the intestinal microbiome of AD mice was significantly improved by RRT quercetin. The results showed that RRT quercetin regulates the intestinal microenvironment, intestinal microbiome and metabolites to improve cognitive function in AD mice.http://www.sciencedirect.com/science/article/pii/S1756464624000483Rosa roxburghii Tratt quercetinAlzheimer’s diseaseIntestinal microbiomesMetabolomics |
| spellingShingle | Tingyuan Ren Zhen Chen Jiao Xie Shuming Tan Yuping Zhu Studies on the role of Rosa roxburghii Tratt quercetin in improving intestinal metabolism and the microbiome in mice with Alzheimer's disease Journal of Functional Foods Rosa roxburghii Tratt quercetin Alzheimer’s disease Intestinal microbiomes Metabolomics |
| title | Studies on the role of Rosa roxburghii Tratt quercetin in improving intestinal metabolism and the microbiome in mice with Alzheimer's disease |
| title_full | Studies on the role of Rosa roxburghii Tratt quercetin in improving intestinal metabolism and the microbiome in mice with Alzheimer's disease |
| title_fullStr | Studies on the role of Rosa roxburghii Tratt quercetin in improving intestinal metabolism and the microbiome in mice with Alzheimer's disease |
| title_full_unstemmed | Studies on the role of Rosa roxburghii Tratt quercetin in improving intestinal metabolism and the microbiome in mice with Alzheimer's disease |
| title_short | Studies on the role of Rosa roxburghii Tratt quercetin in improving intestinal metabolism and the microbiome in mice with Alzheimer's disease |
| title_sort | studies on the role of rosa roxburghii tratt quercetin in improving intestinal metabolism and the microbiome in mice with alzheimer s disease |
| topic | Rosa roxburghii Tratt quercetin Alzheimer’s disease Intestinal microbiomes Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624000483 |
| work_keys_str_mv | AT tingyuanren studiesontheroleofrosaroxburghiitrattquercetininimprovingintestinalmetabolismandthemicrobiomeinmicewithalzheimersdisease AT zhenchen studiesontheroleofrosaroxburghiitrattquercetininimprovingintestinalmetabolismandthemicrobiomeinmicewithalzheimersdisease AT jiaoxie studiesontheroleofrosaroxburghiitrattquercetininimprovingintestinalmetabolismandthemicrobiomeinmicewithalzheimersdisease AT shumingtan studiesontheroleofrosaroxburghiitrattquercetininimprovingintestinalmetabolismandthemicrobiomeinmicewithalzheimersdisease AT yupingzhu studiesontheroleofrosaroxburghiitrattquercetininimprovingintestinalmetabolismandthemicrobiomeinmicewithalzheimersdisease |