RDA coupled with deep sequencing detects somatic SVA-retrotranspositions and mosaicism in the human brain

Cells of the developing human brain are affected by the progressive acquisition of genetic and epigenetic alterations that have been reported to contribute to somatic mosaicism in the adult brain and are increasingly considered a possible cause of neurogenetic disorders. A recent work uncovered that...

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Bibliographic Details
Main Authors: Jonas Möhner, Maurice Scheuren, Valentina Woronzow, Sven Schumann, Hans Zischler
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1201258/full