The K/HDEL receptor does not recycle but instead acts as a Golgi-gatekeeper

The K/HDEL receptor does not recycle but instead acts as a Golgi-gatekeeper

Abstract Accurately measuring the ability of the K/HDEL receptor (ERD2) to retain the ER cargo Amy-HDEL has questioned earlier results on which the popular receptor recycling model is based upon. Here we demonstrate that ERD2 Golgi-retention, rather than fast ER export supports its function. Ligand-...

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Bibliographic Details
Main Authors: Jonas C. Alvim, Robert M. Bolt, Jing An, Yasuko Kamisugi, Andrew Cuming, Fernanda A. L. Silva-Alvim, Juan O. Concha, Luis L. P. daSilva, Meiyi Hu, Dominique Hirsz, Jurgen Denecke
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37056-0

Internet

https://doi.org/10.1038/s41467-023-37056-0

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