The K/HDEL receptor does not recycle but instead acts as a Golgi-gatekeeper
Abstract Accurately measuring the ability of the K/HDEL receptor (ERD2) to retain the ER cargo Amy-HDEL has questioned earlier results on which the popular receptor recycling model is based upon. Here we demonstrate that ERD2 Golgi-retention, rather than fast ER export supports its function. Ligand-...
Main Authors: | Jonas C. Alvim, Robert M. Bolt, Jing An, Yasuko Kamisugi, Andrew Cuming, Fernanda A. L. Silva-Alvim, Juan O. Concha, Luis L. P. daSilva, Meiyi Hu, Dominique Hirsz, Jurgen Denecke |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-03-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-37056-0 |
Similar Items
-
Reply to: Does the KDEL receptor cycle between the Golgi and the ER?
by: Jurgen Denecke
Published: (2024-03-01) -
Taste Receptors: The Gatekeepers of the Airway Epithelium
by: Katleen Martens, et al.
Published: (2021-10-01) -
Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
by: Rakhee Bajaj, et al.
Published: (2022-04-01) -
Becoming the symbol of recycling instead of consumption – 50 years of PET bottles
by: Ferenc Ronkay
Published: (2023-12-01) -
Health Service Gatekeepers.
by: Malcomson, J
Published: (2003)