Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma

Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma

Resistance to cisplatin is the main cause of treatment failure in lung adenocarcinoma. Drug-tolerant-persister (DTP) cells are responsible for intrinsic resistance, since they survive the initial cycles of treatment, representing a reservoir for the emergence of clones that display acquired resistan...

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Bibliographic Details
Main Authors: Rodolfo Chavez-Dominguez, Dolores Aguilar-Cazares, Mario Perez-Medina, Santiago Avila-Rios, Maribel Soto-Nava, Alfonso Mendez-Tenorio, Lorenzo Islas-Vazquez, Jesus J. Benito-Lopez, Miriam Galicia-Velasco, Jose S. Lopez-Gonzalez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Oncology
Subjects:
lung cancer
non-small cell lung carcinoma
lung adenocarcinoma
cisplatin
chemotherapy resistance
intrinsic resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1208403/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1208403/full

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