Induction of UPR Promotes Interferon Response to Inhibit PRRSV Replication via PKR and NF-κB Pathway

Induction of UPR Promotes Interferon Response to Inhibit PRRSV Replication via PKR and NF-κB Pathway

Porcine reproductive and respiratory syndrome virus (PRRSV) was previously shown to induce a certain level of cellular stress during viral replication. Unfolded protein response (UPR) is a cellular stress response responsible for coping with stress and cellular survival. However, the pathway leading...

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Bibliographic Details
Main Authors: Zhenbang Zhu, Panrao Liu, Lili Yuan, Zhengmin Lian, Danhe Hu, Xiaohui Yao, Xiangdong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Microbiology
Subjects:
PRRSV
unfolded protein response
PKR
Nsp4
interferon response
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.757690/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.757690/full

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