Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis

Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis

Osteoarthritic (OA) is characterized by progressive destruction of joint cartilage. Here, the authors show that microRNA-17 plays a dual role in maintaining cartilage homeostasis and in the prevention of osteoarthritis, by targeting hypoxia-inducible factor-1α as well as multiple matrix-degrading en...

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Bibliographic Details
Main Authors: Yun Zhang, Shuaijun Li, Peisheng Jin, Ting Shang, Ruizhu Sun, Laiya Lu, Kaijin Guo, Jiping Liu, Yongjuan Tong, Junbang Wang, Sanhong Liu, Chen Wang, Yubin Kang, Wenmin Zhu, Qian Wang, Xiaoren Zhang, Feng Yin, Yi Eve Sun, Lei Cui
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30119-8

Internet

https://doi.org/10.1038/s41467-022-30119-8

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