Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis that improves diabetes, hyperlipidemia and inflammation. Due to the low oral bioavailability of BBR, its mechanism of action is closely related to the gut microbiota. This study focused on the CYP51 enzyme of intestinal bact...

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Bibliographic Details
Main Authors: Zheng-Wei Zhang, Lin Cong, Ran Peng, Pei Han, Shu-Rong Ma, Li-Bin Pan, Jie Fu, Hang Yu, Yan Wang, Jian-Dong Jiang
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Berberine
Biotransformation
Gut microbiota
CYP51
Demethylated metabolite
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177920310728

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http://www.sciencedirect.com/science/article/pii/S2095177920310728

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