Mitochondrial Transfer by Human Mesenchymal Stromal Cells Ameliorates Hepatocyte Lipid Load in a Mouse Model of NASH

Mitochondrial Transfer by Human Mesenchymal Stromal Cells Ameliorates Hepatocyte Lipid Load in a Mouse Model of NASH

Mesenchymal stromal cell (MSC) transplantation ameliorated hepatic lipid load; tissue inflammation; and fibrosis in rodent animal models of non-alcoholic steatohepatitis (NASH) by as yet largely unknown mechanism(s). In a mouse model of NASH; we transplanted bone marrow-derived MSCs into the livers;...

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Bibliographic Details
Main Authors: Mei-Ju Hsu, Isabel Karkossa, Ingo Schäfer, Madlen Christ, Hagen Kühne, Kristin Schubert, Ulrike E. Rolle-Kampczyk, Stefan Kalkhof, Sandra Nickel, Peter Seibel, Martin von Bergen, Bruno Christ
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomedicines
Subjects:
non-alcoholic steatohepatitis (NASH)
tunneling nanotubes (TNTs)
primary hepatocytes
organelle transfer
mesenchymal stromal cells
Online Access:https://www.mdpi.com/2227-9059/8/9/350

Internet

https://www.mdpi.com/2227-9059/8/9/350

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