CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells

CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells

CD3-epsilon(CD3e) immunotoxins (IT), a promising precision reagent for various clinical conditions requiring effective depletion of T cells, often shows limited treatment efficacy for largely unknown reasons. Tissue-resident T cells that persist in peripheral tissues have been shown to play pivotal...

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Bibliographic Details
Main Authors: Shihyoung Kim, Rajni Kant Shukla, Hannah Yu, Alice Baek, Sophie G. Cressman, Sarah Golconda, Ga-Eun Lee, Hyewon Choi, John C. Reneau, Zhirui Wang, Christene A. Huang, Namal P. M. Liyanage, Sanggu Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
CD3e immunotoxin
tissue-resident T cells
regulatory T cells
tolerance induction
T-cell lymphoma therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011190/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011190/full

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