Development of an immunoassay for the simultaneous detection of GADA and ZnT8A in autoimmune diabetes using a ZnT8/GAD65 chimeric molecule

Development of an immunoassay for the simultaneous detection of GADA and ZnT8A in autoimmune diabetes using a ZnT8/GAD65 chimeric molecule

IntroductionThe combined presence of autoantibodies to the 65 kDa isoform of glutamic acid decarboxylase (GADA) and to the islet-specific cation efflux transporter ZnT8 (ZnT8A) in serum is the best predictive sign of the loss of immune tolerance and the clinical manifestation of autoimmune diabetes...

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Bibliographic Details
Main Authors: Aldana Trabucchi, Silvina Sonia Bombicino, Adriana Victoria Sabljic, Juan Ignacio Marfía, Alexandra Marisa Targovnik, Rubén Francisco Iacono, María Victoria Miranda, Silvina Noemí Valdez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
autoimmune diabetes mellitus
ZnT8/GAD65 chimera
insect cells
autoantibodies
ELISA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219857/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219857/full

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