Zoledronate combined metal-organic frameworks for bone-targeting and drugs deliveries

Abstract Medicine treatments for bone-related diseases such as osteoporosis, bone metastasis, osteomyelitis, and osteolysis are often limited by insufficient drug concentration at the lesion sites owing to the low perfusion of bone tissue. A carrier that can deliver multiple bone destruction site-ta...

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Bibliographic Details
Main Authors: Yixiao Pan, Jiahao Wang, Zichao Jiang, Qi Guo, Zhen Zhang, Jingyi Li, Yihe Hu, Long Wang
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15941-w