Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells

Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells

In the course of our continuous investigation on the bioactive marine-derived fungal metabolites, terrein was isolated from marine-derived fungal strain Penicillium sp. SF-7181. Terrein inhibited the overproduction of pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2),...

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Bibliographic Details
Main Authors: Kwan-Woo Kim, Hye Jin Kim, Jae Hak Sohn, Joung Han Yim, Youn-Chul Kim, Hyuncheol Oh
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Journal of Pharmacological Sciences
Subjects:
Terrein
Anti-neuroinflammatory effects
NF-κB
HO-1
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300190

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http://www.sciencedirect.com/science/article/pii/S1347861320300190

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