Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor

Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor

Abstract Background Thioredoxin-1 (TXN1) is one of the major cellular antioxidants in mammals and is involved in a wide range of physiological cellular responses. However, little is known about the roles and the underlying molecular mechanisms of TXN1 in the regulation of hematopoietic stem/progenit...

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Bibliographic Details
Main Authors: Shaima Jabbar, Parker Mathews, Xiaobei Wang, Pasupathi Sundaramoorthy, Emily Chu, Sadhna O. Piryani, Shengli Ding, Xiling Shen, Phuong L. Doan, Yubin Kang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Experimental Hematology & Oncology
Subjects:
Hematopoietic stem cells
Radiation mitigation
Hematopoietic stem cell transplant
Reactive oxygen species
p53
Redox homeostasis
Online Access:https://doi.org/10.1186/s40164-022-00329-3

Internet

https://doi.org/10.1186/s40164-022-00329-3

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