Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1

Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1

Ferroptosis is a type of programmed necrosis triggered by iron-dependent lipid peroxidation. We investigated the role of B-cell translocation gene 1 (BTG1) in cystine and methionine deficiency (CST/Met (−))-mediated cell death. CST/Met (−) depleted reduced and oxidized glutathione in hepatocyte-deri...

Full description

Bibliographic Details
Main Authors: Il-Je Cho, Doyeon Kim, Eun-Ok Kim, Kyung-Hwan Jegal, Jae-Kwang Kim, Sang-Mi Park, Rongjie Zhao, Sung-Hwan Ki, Sang-Chan Kim, Sae-Kwang Ku
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Antioxidants
Subjects:
activating transcription factor 4 (ATF4)
B-cell translocation gene 1 (BTG1)
cystine and methionine deficiency (CST/Met (−))
ferroptosis
hepatocyte-derived cells
Online Access:https://www.mdpi.com/2076-3921/10/10/1543

Internet

https://www.mdpi.com/2076-3921/10/10/1543

Similar Items