Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1

Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1

Ferroptosis is a type of programmed necrosis triggered by iron-dependent lipid peroxidation. We investigated the role of B-cell translocation gene 1 (BTG1) in cystine and methionine deficiency (CST/Met (−))-mediated cell death. CST/Met (−) depleted reduced and oxidized glutathione in hepatocyte-deri...

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Bibliographic Details
Main Authors:	Il-Je Cho, Doyeon Kim, Eun-Ok Kim, Kyung-Hwan Jegal, Jae-Kwang Kim, Sang-Mi Park, Rongjie Zhao, Sung-Hwan Ki, Sang-Chan Kim, Sae-Kwang Ku
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Antioxidants
Subjects:	activating transcription factor 4 (ATF4) B-cell translocation gene 1 (BTG1) cystine and methionine deficiency (CST/Met (−)) ferroptosis hepatocyte-derived cells
Online Access:	https://www.mdpi.com/2076-3921/10/10/1543

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