Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers
Cancer whole-genome and transcriptome sequencing (cWGTS) has been challenging to implement in clinical settings. Here, the authors develop a workflow to deliver robust cWGTS analyses and reports within clinically-relevant timeframes for paediatric, adolescent and young adult solid tumour patients.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30233-7 |
| _version_ | 1818238755426795520 |
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| author | N. Shukla M. F. Levine G. Gundem D. Domenico B. Spitzer N. Bouvier J. E. Arango-Ossa D. Glodzik J. S. Medina-Martínez U. Bhanot J. Gutiérrez-Abril Y. Zhou E. Fiala E. Stockfisch S. Li M. I. Rodriguez-Sanchez T. O’Donohue C. Cobbs M. H. A. Roehrl J. Benhamida F. Iglesias Cardenas M. Ortiz M. Kinnaman S. Roberts M. Ladanyi S. Modak S. Farouk-Sait E. Slotkin M. A. Karajannis F. Dela Cruz J. Glade Bender A. Zehir A. Viale M. F. Walsh A. L. Kung E. Papaemmanuil |
| author_facet | N. Shukla M. F. Levine G. Gundem D. Domenico B. Spitzer N. Bouvier J. E. Arango-Ossa D. Glodzik J. S. Medina-Martínez U. Bhanot J. Gutiérrez-Abril Y. Zhou E. Fiala E. Stockfisch S. Li M. I. Rodriguez-Sanchez T. O’Donohue C. Cobbs M. H. A. Roehrl J. Benhamida F. Iglesias Cardenas M. Ortiz M. Kinnaman S. Roberts M. Ladanyi S. Modak S. Farouk-Sait E. Slotkin M. A. Karajannis F. Dela Cruz J. Glade Bender A. Zehir A. Viale M. F. Walsh A. L. Kung E. Papaemmanuil |
| author_sort | N. Shukla |
| collection | DOAJ |
| description | Cancer whole-genome and transcriptome sequencing (cWGTS) has been challenging to implement in clinical settings. Here, the authors develop a workflow to deliver robust cWGTS analyses and reports within clinically-relevant timeframes for paediatric, adolescent and young adult solid tumour patients. |
| first_indexed | 2024-12-12T12:46:42Z |
| format | Article |
| id | doaj.art-3b93b91639d74dfb8d599ab92c782f7b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T12:46:42Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3b93b91639d74dfb8d599ab92c782f7b2022-12-22T00:24:06ZengNature PortfolioNature Communications2041-17232022-05-0113111510.1038/s41467-022-30233-7Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancersN. Shukla0M. F. Levine1G. Gundem2D. Domenico3B. Spitzer4N. Bouvier5J. E. Arango-Ossa6D. Glodzik7J. S. Medina-Martínez8U. Bhanot9J. Gutiérrez-Abril10Y. Zhou11E. Fiala12E. Stockfisch13S. Li14M. I. Rodriguez-Sanchez15T. O’Donohue16C. Cobbs17M. H. A. Roehrl18J. Benhamida19F. Iglesias Cardenas20M. Ortiz21M. Kinnaman22S. Roberts23M. Ladanyi24S. Modak25S. Farouk-Sait26E. Slotkin27M. A. Karajannis28F. Dela Cruz29J. Glade Bender30A. Zehir31A. Viale32M. F. Walsh33A. L. Kung34E. Papaemmanuil35Department of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterIntegrated Genomics Operation Core, Center for Molecular Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterIntegrated Genomics Operation Core, Center for Molecular Oncology, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterDepartment of Pediatrics, Memorial Sloan Kettering Cancer CenterCancer whole-genome and transcriptome sequencing (cWGTS) has been challenging to implement in clinical settings. Here, the authors develop a workflow to deliver robust cWGTS analyses and reports within clinically-relevant timeframes for paediatric, adolescent and young adult solid tumour patients.https://doi.org/10.1038/s41467-022-30233-7 |
| spellingShingle | N. Shukla M. F. Levine G. Gundem D. Domenico B. Spitzer N. Bouvier J. E. Arango-Ossa D. Glodzik J. S. Medina-Martínez U. Bhanot J. Gutiérrez-Abril Y. Zhou E. Fiala E. Stockfisch S. Li M. I. Rodriguez-Sanchez T. O’Donohue C. Cobbs M. H. A. Roehrl J. Benhamida F. Iglesias Cardenas M. Ortiz M. Kinnaman S. Roberts M. Ladanyi S. Modak S. Farouk-Sait E. Slotkin M. A. Karajannis F. Dela Cruz J. Glade Bender A. Zehir A. Viale M. F. Walsh A. L. Kung E. Papaemmanuil Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers Nature Communications |
| title | Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers |
| title_full | Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers |
| title_fullStr | Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers |
| title_full_unstemmed | Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers |
| title_short | Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers |
| title_sort | feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers |
| url | https://doi.org/10.1038/s41467-022-30233-7 |
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