Cholesterol Crystal-Mediated Inflammation Is Driven by Plasma Membrane Destabilization

Cholesterol Crystal-Mediated Inflammation Is Driven by Plasma Membrane Destabilization

Atherosclerosis is driven by an inflammatory milieu in the walls of artery vessels. Initiated early in life, it progresses to plaque formation and form cell accumulation. A culprit in this cascade is the deposition of cholesterol crystals (CC). The involvement of smaller crystals in the early stage...

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Bibliographic Details
Main Authors: Fei Shu, Jiahuan Chen, Xiaojie Ma, Yunzhou Fan, Li Yu, Wencheng Zheng, Matthias W. Amrein, Tie Xia, Yan Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
cholesterol crystals
cell death
inflammation
membrane rupture
signal free
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01163/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01163/full

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