A Novel Sustained Anti-Inflammatory Effect of Atorvastatin—Calcium PLGA Nanoparticles: In Vitro Optimization and In Vivo Evaluation

A Novel Sustained Anti-Inflammatory Effect of Atorvastatin—Calcium PLGA Nanoparticles: In Vitro Optimization and In Vivo Evaluation

Atorvastatin Calcium (At-Ca) has pleiotropic effect as anti-inflammatory drug beside its main antihyperlipidemic action. Our study was conducted to modulate the anti-inflammatory effect of At-Ca to be efficiently sustained for longer time. Single oil-water emulsion solvent evaporation technique was...

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Bibliographic Details
Main Authors: Dalia H. Abdelkader, Ahmed Kh. Abosalha, Mohamed A. Khattab, Basmah N. Aldosari, Alanood S. Almurshedi
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
atorvastatin calcium
poly(lactide-co-glycolide)
polymeric nanoparticles
carrageenan induced inflammation
anti-inflammatory
sustained release
Online Access:https://www.mdpi.com/1999-4923/13/10/1658

Internet

https://www.mdpi.com/1999-4923/13/10/1658

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