mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells

mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells

mTOR activation is a hallmark of T-cell acute lymphoblastic leukemia (T-ALL) and is associated with resistance to glucocorticoid (GC)-based chemotherapy. We previously showed that altering redox homeostasis primes T-ALL cells to GC-induced apoptosis. Here we investigated the connection between the m...

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Bibliographic Details
Main Authors: Micol Silic-Benussi, Evgenyia Sharova, Francesco Ciccarese, Ilaria Cavallari, Vittoria Raimondi, Loredana Urso, Alberto Corradin, Harel Kotler, Gloria Scattolin, Barbara Buldini, Samuela Francescato, Giuseppe Basso, Sonia A. Minuzzo, Stefano Indraccolo, Donna M. D'Agostino, Vincenzo Ciminale
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Redox Biology
Subjects:
T-ALL
mTOR
G6PD
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000404

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http://www.sciencedirect.com/science/article/pii/S2213231722000404

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