A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

ABSTRACT The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB with significant potency against various clinical...

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Main Authors: J. Hiroshi Morisaki, Peter A. Smith, Shailesh V. Date, Kimberly K. Kajihara, Chau Linda Truong, Zora Modrusan, Donghong Yan, Jing Kang, Min Xu, Ishita M. Shah, Robert Mintzer, Eric M. Kofoed, Tommy K. Cheung, David Arnott, Michael F. T. Koehler, Christopher E. Heise, Eric J. Brown, Man-Wah Tan, Wouter L. W. Hazenbos
Format: Article
Language:English
Published: American Society for Microbiology 2016-11-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00412-16

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https://journals.asm.org/doi/10.1128/mBio.00412-16

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