Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

Summary: Posttranslational modifications represent a key step in modulating programmed death-1 (PD-1) functions, but the underlying mechanisms remain incompletely defined. Here, we report crosstalk between deglycosylation and ubiquitination in regulating PD-1 stability. We show that the removal of N...

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Bibliographic Details
Main Authors: Zhen Wu, Zhijie Cao, Han Yao, Xiaojun Yan, Wenbin Xu, Mi Zhang, Zishan Jiao, Zijing Zhang, Jianyuan Chen, Yajing Liu, Meng Zhang, Donglai Wang
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723007040

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http://www.sciencedirect.com/science/article/pii/S2211124723007040

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