Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis

Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis

Leishmaniasis is a disease caused by Leishmania spp., affecting millions of people around the world. For decades, its treatment has been based on pentavalent antimonials, which notoriously cause toxic side effects in patients. In this study, epoxy-α-lapachone incorporated into an oil-in-water-type m...

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Bibliographic Details
Main Authors: Juliana Figueiredo Peixoto, Luiz Filipe Gonçalves-Oliveira, Franklin Souza-Silva, Luzia Monteiro de Castro Côrtes, Léa Cysne Finkelstein, Geovane Dias-Lopes, Beatriz Ferreira de Carvalho Patricio, Carolina Guimarães de Souza Lima, Helvécio Vinícius Antunes Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Bernardo Acácio Santini Pereira, Carlos Roberto Alves
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Leishmania (Leishmania) amazonensis
Cutaneous leishmaniasis treatment
Combination therapy
Meglumine antimoniate
Glucantime
Epoxy-α-lapachone
Online Access:http://www.sciencedirect.com/science/article/pii/S221132072400006X

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http://www.sciencedirect.com/science/article/pii/S221132072400006X

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