Isothiocyanates (ITCs) 1-(Isothiocyanatomethyl)-4-phenylbenzene and 1-Isothiocyanato-3,5-bis(trifluoromethyl)benzene—Aldehyde Dehydrogenase (ALDH) Inhibitors, Decreases Cisplatin Tolerance and Migratory Ability of NSCLC

Isothiocyanates (ITCs) 1-(Isothiocyanatomethyl)-4-phenylbenzene and 1-Isothiocyanato-3,5-bis(trifluoromethyl)benzene—Aldehyde Dehydrogenase (ALDH) Inhibitors, Decreases Cisplatin Tolerance and Migratory Ability of NSCLC

One of the main treatment modalities for non-small-cell lung cancer (NSCLC) is cisplatin-based chemotherapy. However, the acquisition of cisplatin resistance remains a major problem. Existing chemotherapy regimens are often ineffective against cancer cells expressing aldehyde dehydrogenase (ALDH). A...

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Bibliographic Details
Main Authors: Jolanta Kryczka, Jakub Kryczka, Łukasz Janczewski, Anna Gajda, Andrzej Frączyk, Joanna Boncela, Beata Kolesińska, Ewa Brzeziańska-Lasota
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
non-small-cell lung cancer
cisplatin resistance
aldehyde dehydrogenase
isothiocyanates
disulfiram
epithelial to mesenchymal transition
Online Access:https://www.mdpi.com/1422-0067/23/15/8644

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https://www.mdpi.com/1422-0067/23/15/8644

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