Molecular analysis of cyclin D1 modulators PRKN and FBX4 as candidate tumor suppressors in sporadic parathyroid adenomas

Objective: Primary hyperparathyroidism is most often caused by a sporadic single-gland parathyroid adenoma (PTA), a tumor type for which cyclin D1 is the only known and experimentally validated oncoprotein. However, the molecular origins of its frequent overexpression have remained mostly elusive. I...

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Bibliographic Details
Main Authors: Kelly Brewer, Isabel Nip, Justin Bellizzi, Jessica Costa-Guda, Andrew Arnold
Format: Article
Language:English
Published: Bioscientifica 2021-04-01
Series:Endocrine Connections
Subjects:
Online Access:https://ec.bioscientifica.com/view/journals/ec/10/3/EC-21-0055.xml