Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.

Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.

Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp). Despite significant in vitro activities versus several pharma...

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Main Authors: Romina Croci, Margherita Pezzullo, Delia Tarantino, Mario Milani, Shwu-Chen Tsay, Radhakrishnan Sureshbabu, Yi-Jin Tsai, Eloise Mastrangelo, Jacques Rohayem, Martino Bolognesi, Jih Ru Hwu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3951423?pdf=render

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http://europepmc.org/articles/PMC3951423?pdf=render

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