Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesis

Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesis

Abstract Background Mutations in TP53 gene is considered a main driver of hepatocellular carcinoma (HCC). While TP53 mutations are the leading cause of p53 dysfunction, their occurrence rates may drop to approximately 10% in cohorts without hepatitis B virus and aflatoxin exposure. This observation...

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Bibliographic Details
Main Authors: Chun Wang, Hui Kang, Yun Yi, Yang Ding, Fan Wang, Jie Luo, Mingliang Ye, Yinghui Hong, Chao Xia, Junwei Yan, Lan Liu, Jing Liu, Zibiao Zhong, Zhonglin Zhang, Qiu Zhao, Ying Chang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Translational Medicine
Subjects:
Hepatocellular carcinoma
Rictor
TP53
microRNA-192
Nucleocytoplasmic shuttle
Wild-type
Online Access:https://doi.org/10.1186/s12967-023-04799-9

Internet

https://doi.org/10.1186/s12967-023-04799-9

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