Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

Abstract Individuals with Parkinson’s disease (PD) typically receive a diagnosis once they have developed motor symptoms, at which point there is already significant loss of substantia nigra dopamine neurons, α-synuclein accumulation in surviving neurons, and neuroinflammation. Consequently, the poi...

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Bibliographic Details
Main Authors: Amber D. Van Laar, Katherine R. Webb, Matthew T. Keeney, Victor S. Van Laar, Alevtina Zharikov, Edward A. Burton, Teresa G. Hastings, Kelly E. Glajch, Warren D. Hirst, J. Timothy Greenamyre, Emily M. Rocha
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00561-6

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https://doi.org/10.1038/s41531-023-00561-6

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