A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation

A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation

R-loops are non-canonical, three-stranded nucleic acid structures composed of a DNA:RNA hybrid, a displaced single-stranded (ss)DNA, and a trailing ssRNA overhang. R-loops perform critical biological functions under both normal and disease conditions. To elucidate their cellular functions, we need t...

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Bibliographic Details
Main Authors: Leonardo G. Dettori, Diego Torrejon, Arijita Chakraborty, Arijit Dutta, Mohamed Mohamed, Csaba Papp, Vladimir A. Kuznetsov, Patrick Sung, Wenyi Feng, Alaji Bah
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
R-loops
intrinscially disordered regions
R-loop interactome
liquid-liquid phase separation
R-loop readers
R-loop processing enzymes
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.691694/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.691694/full

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