Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate
Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine. The chiral hemiacetal fragment is constructed...
| Główni autorzy: | , , , |
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| Format: | Artykuł |
| Język: | English |
| Wydane: |
MDPI AG
2018-06-01
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| Seria: | Molecules |
| Hasła przedmiotowe: | |
| Dostęp online: | http://www.mdpi.com/1420-3049/23/6/1440 |