Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

Abstract Background People living with HIV (PLWH) are at increased risk of developing Chronic Obstructive Pulmonary Disease (COPD) independent of cigarette smoking. We hypothesized that dysbiosis in PLWH is associated with epigenetic and transcriptomic disruptions in the airway epithelium. Methods A...

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Bibliographic Details
Main Authors: Marcia Smiti Jude, Chen Xi Yang, Fernando Studart Leitao Filho, Ana I. Hernandez Cordero, Julia Yang, Tawimas Shaipanich, Xuan Li, David Lin, Julie MacIsaac, Michael S. Kobor, Sunita Sinha, Corey Nislow, Amrit Singh, Wan Lam, Stephen Lam, Silvia Guillemi, Marianne Harris, Julio Montaner, Raymond T. Ng, Christopher Carlsten, S. F. Paul Man, Don D. Sin, Janice M. Leung
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Respiratory Research
Subjects:
HIV
COPD
Microbiome
Airway epithelium
Methylation
Transcriptome
Online Access:https://doi.org/10.1186/s12931-023-02431-4

Internet

https://doi.org/10.1186/s12931-023-02431-4

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