The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in <i>BRCA1/BRCA2/PALB2</i>-Negative Women

The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in <i>BRCA1/BRCA2/PALB2</i>-Negative Women

Background: Contralateral breast cancer (CBC) is associated with younger age at first diagnosis, family history and pathogenic germline variants (PGVs) in genes such as <i>BRCA1, BRCA2</i> and <i>PALB2.</i> However, data regarding genetic factors predisposing to CBC among you...

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Bibliographic Details
Main Authors: Alexey Larionov, Eleanor Fewings, James Redman, Mae Goldgraben, Graeme Clark, John Boice, Patrick Concannon, Jonine Bernstein, David V. Conti, the WECARE Study Collaborative Group, Marc Tischkowitz
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
contralateral breast cancer
hereditary breast cancer
exome sequencing
genomics
Online Access:https://www.mdpi.com/2072-6694/15/2/415

Internet

https://www.mdpi.com/2072-6694/15/2/415

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