In silico and in vivo evaluations of fisetin and fisetin-loaded nanosuspension on monoamine oxidase inhibition in Aβ(25–35) induced dementia in mice model

In silico and in vivo evaluations of fisetin and fisetin-loaded nanosuspension on monoamine oxidase inhibition in Aβ(25–35) induced dementia in mice model

Background: Amyloid beta (Aβ) plaques on the extracellular matrix and intracellular neurofibrillary tangles comprise the key indicative pathology of Alzheimer's disease (AD). Fisetin, an antioxidant bioactive compound having pharmacotherapeutic effects is applied by traditional Chinese medicine...

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Bibliographic Details
Main Authors: Siti Zaidathul Iman Zolkiffly, Mizaton Hazizul Hasan, Siti Azma Jusoh, Ashok Kumar Janakiraman, Sathesh Kumar Sukumaran, Noreen Husain, Yuslina Zakaria, Hanish Singh Jayasingh Chellammal
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research - Modern Chinese Medicine
Subjects:
Alzheimer's disease
Fisetin
Traditional Chinese medicine
Nanosuspension
Docking studies
Monoamine oxidase
Online Access:http://www.sciencedirect.com/science/article/pii/S2667142524001891

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http://www.sciencedirect.com/science/article/pii/S2667142524001891

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