Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design

Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design

Today it is widely recognized that the PD-1/PD-L1 axis plays a fundamental role in escaping the immune system in cancers, so that anti-PD-1/PD-L1 antibodies have been evaluated for their antitumor properties in more than 1000 clinical trials. As a result, some of them have entered the market revolut...

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Bibliographic Details
Main Authors: Greta Donati, Vincenzo Maria D’Amore, Pasquale Russomanno, Linda Cerofolini, Jussara Amato, Simona Marzano, Maria Salobehaj, Domenico Rizzo, Giulia Assoni, Alfonso Carotenuto, Valeria La Pietra, Daniela Arosio, Pierfausto Seneci, Marco Fragai, Diego Brancaccio, Francesco Saverio Di Leva, Luciana Marinelli
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Immunotherapy
Cancer
Programmed Death Ligand 1
Computational Chemistry
Drug Design
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023002209

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http://www.sciencedirect.com/science/article/pii/S2001037023002209

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