Validation of HPLC and Liquid-Liquid Extraction Methods for Warfarin Detection in Human Plasma and its Application to a Pharmacokinetics Study

Validation of HPLC and Liquid-Liquid Extraction Methods for Warfarin Detection in Human Plasma and its Application to a Pharmacokinetics Study

A reversed-phase HPLC method to determine total plasma warfarin was developed and validated. Warfarin was extracted from human plasma using a two-step liquid-liquid extraction method. The residue was reconstituted with a phenylbutazone standard solution, which was used as the internal standard. The...

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Bibliographic Details
Main Authors: Yung An Chua, Wan Zaidah Abdullah, Zurkurnai Yusof, Siew Hua Gan
Format: Article
Language:English
Published: Academy of Sciences Malaysia 2019-06-01
Series:ASM Science Journal
Subjects:
hplc
liquid-liquid extraction
method validation
pharmacokinetics
warfarin
Online Access:https://doi.org/10.32802/asmscj.2019.215

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