Reciprocal Regulation of MAGED2 and HIF-1α Augments Their Expression under Hypoxia: Role of cAMP and PKA Type II

Reciprocal Regulation of MAGED2 and HIF-1α Augments Their Expression under Hypoxia: Role of cAMP and PKA Type II

Hypoxia stabilizes the transcription factor HIF-1α, which promotes the transcription of many genes essential to adapt to reduced oxygen levels. Besides proline hydroxylation, expression of HIF-1α is also regulated by a range of other posttranslational modifications including phosphorylation by cAMP-...

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Bibliographic Details
Main Authors: Elie Seaayfan, Sadiq Nasrah, Lea Quell, Aline Radi, Maja Kleim, Ralph T. Schermuly, Stefanie Weber, Kamel Laghmani, Martin Kömhoff
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
MAGED2
hypoxia
HIF-1α
GalphaS
PKA type II
Bartter
Online Access:https://www.mdpi.com/2073-4409/11/21/3424

Internet

https://www.mdpi.com/2073-4409/11/21/3424

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