NT5E upregulation in head and neck squamous cell carcinoma: A novel biomarker on cancer-associated fibroblasts for predicting immunosuppressive tumor microenvironment

Despite tremendous progress made in the diagnosis and managements, head and neck squamous cell carcinoma (HNSC) remains a global medical dilemma with dismal clinical prognosis and high mortality. Gene NT5E encodes the ecto-5’-nucleotidase (CD73), which facilitates the formation of immunosuppressive...

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Bibliographic Details
Main Authors: Xue-min Chen, Yu-yang Liu, Bing-yan Tao, Xin-miao Xue, Xin-xin Zhang, Lin-lin Wang, Hui Zhong, Jun Zhang, Shi-ming Yang, Qing-qing Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.975847/full