Amphiphilic cationic triblock polymers for p53-mediated triple-negative breast cancer gene therapy

Amphiphilic cationic triblock polymers for p53-mediated triple-negative breast cancer gene therapy

Polycationic vectors are a promising class of gene delivery systems. To improve delivery efficiency and reduce cytotoxicity, hydrophobic modification has been proposed as an effective way. Herein, we synthesized a class of terpolymer vectors with various hydrophobicities as well as multiple biodegra...

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Bibliographic Details
Main Authors: Hui Liu, Xiaoyun Zhao, Yu Bai, Huichao Xie, Zhen Yang, Yichen Wang, Yongfeng Chen, Yucen Luo, Mengrui Ma, Wenwen Lu, Jizhuang Ma, Tianzhi Yang, Bo Jin, Pingtian Ding
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Materials & Design
Subjects:
Gene therapy
Cationic polymer
Hydrophilic-hydrophobic balance
Wtp53
Transfection efficiency
Tumor growth suppression
Online Access:http://www.sciencedirect.com/science/article/pii/S026412752200380X

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http://www.sciencedirect.com/science/article/pii/S026412752200380X

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