Age-dependent methylation in epigenetic clock CpGs is associated with G-quadruplex, co-transcriptionally formed RNA structures and tentative splice sites

Age-dependent methylation in epigenetic clock CpGs is associated with G-quadruplex, co-transcriptionally formed RNA structures and tentative splice sites

Horvath’s epigenetic clock consists of 353 CpGs whose methylation levels can accurately predict the age of individuals. Using bioinformatics analysis, we investigated the conformation, energy characteristics and presence of tentative splice sites of the sequences surrounding the epigenetic clock CpG...

Full description

Bibliographic Details
Main Authors: Andigoni Malousi, Alexandra-Zoi Andreou, Elisavet Georgiou, Georgios Tzimagiorgis, Leda Kovatsi, Sofia Kouidou
Format: Article
Language:English
Published: Taylor & Francis Group 2018-08-01
Series:Epigenetics
Subjects:
dna methylation
aging
epigenetic clock
g-quadruplex
alternative splicing
co-transcriptionally formed rna structures
hypothetical proteins
tentative splice sites
Online Access:http://dx.doi.org/10.1080/15592294.2018.1514232

Internet

http://dx.doi.org/10.1080/15592294.2018.1514232

Similar Items